Puma Biotechnology, Inc. (PBYI) Fair Value 2026

PBYI · Biotechnology ·

By CirclFi Research Team · Data from SEC EDGAR, FRED & GDELT

Quality Score

8.7 /10

32 fundamental signals · 9 models active

Value Trap Risk

SAFE (12/100)

Quick Summary — As of 2026-08-28, Puma Biotechnology, Inc. (PBYI) trades at $9.06, versus a $3.57 median fair value across its 9 active models — 60.6% below the current price. QOC: 8.7/10. Value Trap Risk: 12/100 (SAFE). 9/13 models active. Within that set, the Bayesian DCF component alone returns $7.16.

Key Facts

Ticker
PBYI
Price
$9.06
Quality Score
8.7/10
Value Trap Risk
12/100
Models Active
9/13
Last Updated
Strength: Quality Score of 8.7/10 indicates strong fundamentals
Risk: Majority of models suggest overvaluation

Is Puma Biotechnology, Inc. (PBYI) Undervalued or Overvalued in 2026?

According to CirclFi’s 9-model valuation engine, Puma Biotechnology, Inc. (PBYI) appears overvalued as of : the median of 9 independent fair value estimates is $3.57, 60.6% below the current price of $9.06. Estimates range from $1.54 to $9.76. PBYI scores 8.7/10 on fundamental quality and 12/100 on value-trap risk.

For context, the median US equity CirclFi rates trades at an implied -23.4% versus its own 13-model consensus, across 3,809 rated companies as of 2026-08-28. PBYI’s -60.6% gap is wider than that market norm, and the Biotechnology sector median is -64.7%. Full market index →

This verdict compares price to intrinsic value only — it is not a buy or sell rating. For the decision case (bull vs bear arguments, risk factors, peers), read Should You Buy Puma Biotechnology, Inc. Stock in 2026? →

What Fair Value Does Each Model Give PBYI?

9 Intrinsic Value Models vs. Current Price ($9.06)

Core Models (Unlocked)
Model Fair Value Upside
Intrinsic · High Conviction
 $7.16 -20.9%
Intrinsic · High Conviction
 $1.98 -78.2%
Ensemble · Low Conviction
 $5.26 -41.9%
Intrinsic · High Conviction
 $8.73 -3.6%
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What Is PBYI's Fair Value Range?

Spread across 9 independent models · $1.54 to $9.76

CirclFi's 9 active models place Puma Biotechnology, Inc. (PBYI) between $1.54 and $9.76 per share, a spread of 230% of the median. The median of that range — $3.57 — is the fair value CirclFi publishes for PBYI, against a current price of $9.06.

Low · Regime CrossHigh · RCMH-DCF
$1.54median $3.57$9.76
Where the range comes from
Most bearish modelRegime Cross-Sectional$1.54
Most bullish modelRCMH-DCF$9.76
Model agreement1 bullish · 7 bearishwide

A band this wide is itself the finding. When independent methods land far apart, they are reading a business whose value depends heavily on which lens you apply — volatile earnings, heavy reinvestment, or an asset base that cash-flow and asset-based methods score differently. That disagreement is information: it says the choice of method matters more than usual for PBYI. Treat the median as one reading among several and compare the individual models below before acting.

Every figure above is one model's standalone output on PBYI, not a CirclFi price target. How each model works →

What Is Puma Biotechnology, Inc. (PBYI) Worth in 2026?

According to the CirclFi Deep Alpha Valuation Engine, Puma Biotechnology, Inc.'s intrinsic value is estimated at $3.57. Trading at its current price of $9.06, the valuation engine raises significant caution: 7 of 9 models flag downside risk, projecting a median implied return of -60.6%. Model dispersion is worth noting: RCMH-DCF targets $9.76 (+7.7%), versus Regime Cross at $1.54 (-83.0%). This +90.7% range highlights the importance of multi-model analysis rather than relying on any single methodology. Among models with highest confidence, Bayesian DCF, EPV lean bearish — adding weight to the bearish side of the thesis.

What Do the Models Say About PBYI?

9 of 13 models are currently active for PBYI. Of these, 1 model suggests upside while 8 models suggest overvaluation. Taken together, their median fair value for PBYI is $3.57 — the figure CirclFi publishes as this stock's fair value. One component of that median, the Bayesian DCF, returns $7.16 on its own, implying -20.9% downside from the current price. See which stocks rank higher →

How Does PBYI Rank in Biotechnology?

Among 625 Biotechnology stocks, PBYI ranks #13 by Quality of Company score. CirclFi's QOC score of 8.7/10 evaluates 32 fundamental signals. A score of 8.7 places PBYI in the top tier.

See all Most Undervalued Biotechnology Stocks →

The Biotechnology sector introduces analytical considerations specific to biotechnology enterprise businesses. For Puma Biotechnology, Inc., metrics like R&D burn rate provide important context that general-purpose valuation models may underweight.

Is PBYI a Value Trap?

CirclFi's Value Trap algorithm assigns PBYI a score of 12/100 (SAFE). This indicates minimal risk. Fundamentals are healthy. The score cross-references apparent undervaluation against fundamental deterioration signals. Browse lowest value-trap stocks →

Multi-Model Methodology

9 of 13 models are active for Puma Biotechnology, Inc.. Moderate coverage provides meaningful perspective. Each model applies a fundamentally different valuation philosophy. See the complete methodology →

According to the CirclFi Deep Alpha Valuation Engine, Puma Biotechnology, Inc. scores 8.7 out of 10 on our 32-signal quality assessment, a strong rating that demonstrates strong fundamentals across the majority of our quality signals. The QOC score synthesizes profitability margins, revenue growth reliability, debt management, and capital allocation into a single metric designed to separate durable businesses from statistically cheap ones.

The gap between the most bullish and bearish model spans +90.7% — demonstrating why single-model analysis is dangerous. Browse all stocks with 13-model coverage →

Data Sources & Confidence

Every PBYI valuation is built from SEC EDGAR XBRL filings — 700+ standardized financial tags. Macroeconomic context from FRED calibrates discount rates, while GDELT news sentiment feeds into our Sentiment SOTP model. All pipelines run daily. Read the complete data methodology →

Across PBYI's 9 active models, average confidence is 50%. Moderate confidence indicates reasonable fit.

CirclFi's output is a research starting point, not a buy/sell signal. All data updates daily. Read the full methodology →

This analysis is produced by the CirclFi Valuation Engine using quantitative models applied to SEC EDGAR filings, public market feeds, and FRED macroeconomic indicators. It is not financial advice.

Read the full investment analysis: Should You Buy Puma Biotechnology, Inc. Stock in 2026? →

Bull case, bear case, risk factors & peer comparison — updated daily

Which Similar Biotechnology Stocks Should You Also Analyze?

11 related Biotechnology stocks with 13-model coverage

PTCTPTC Therapeutics, Inc.QOC 8.7MDXGMiMedx Group, Inc.QOC 8.7VCELVericel CorporationQOC 8.8NAGENiagen Bioscience, Inc.QOC 8.6CGENCompugen Ltd.QOC 9.0BMRNBioMarin Pharmaceutical Inc.QOC 8.6MRVIMaravai LifeSciences Holdings, Inc.QOC 5.8TCRTAlaunos Therapeutics, Inc.QOC 5.0BYSIBeyondSpring Inc.QOC 4.3EXELExelixis, Inc.QOC 9.6INCYIncyte CorporationQOC 9.5

Read investment analysis: PTCT · MDXG · VCEL · NAGE · CGEN · BMRN · MRVI · TCRT · BYSI · EXEL · INCY

Which Other Stocks Have a Similar Quality Score to PBYI?

6 companies across all industries closest to PBYI’s Quality of Company score of 8.7/10.

CVCOCavco Industries, Inc.QOC 8.7SLBKSkyline Bankshares, Inc.QOC 8.7NWPPNew Peoples Bankshares, Inc.QOC 8.7TUYATuya Inc.QOC 8.7NHCNational HealthCare CorporationQOC 8.7NVDANVIDIA CorporationQOC 10.0

Read investment analysis: CVCO · SLBK · NWPP · TUYA · NHC · NVDA

Where Does PBYI Sit in CirclFi's Biotechnology Rankings?

PBYI is ranked against every other Biotechnology stock CirclFi covers in each of these screens.

See all Biotechnology stocks ranked →

What Else Do Investors Ask About Puma Biotechnology, Inc.’s Valuation?

What is Puma Biotechnology, Inc.'s intrinsic value in 2026?

CirclFi puts Puma Biotechnology, Inc. (PBYI)'s intrinsic value at $3.57 — the median of 9 independent model estimates as of 2026-08-28, ranging from $1.54 to $9.76. One component of that median, the Bayesian DCF, runs 10,000 Monte Carlo simulations with jump-diffusion and returns $7.16 on its own. The Quality of Company score is 8.7/10 across 32 fundamental signals. All models use SEC EDGAR filings updated daily. See our methodology page for how each model works.

Is PBYI overvalued or undervalued right now?

At $9.06, 1 of 9 active models suggest PBYI may be undervalued, while 8 indicate potential overvaluation. The median of all 9 fair value estimates is $3.57, 60.6% below the current price of $9.06 — a consensus view that PBYI is overvalued. The assessment depends on which methodology best fits Puma Biotechnology, Inc.'s business model in Biotechnology.

What does a Quality of Company score of 8.7 mean for PBYI?

Puma Biotechnology, Inc.'s QOC of 8.7/10 reflects 32 fundamental signals: profitability margins, revenue growth consistency, balance sheet leverage, free cash flow generation, and capital allocation efficiency. Scores above 7 indicate strong fundamentals and disciplined management.

How many valuation models does CirclFi run on PBYI?

CirclFi analyzes PBYI with 13 institutional-grade models daily: Bayesian DCF (Monte Carlo + jump-diffusion), EPV (Greenwald zero-growth), EROIC Spread (McKinsey reinvestment), First Chicago (3-scenario), Markov DDM (regime-switching), ML-RIV (machine learning residual income), Dynamic NAV (asset-based), PWERM (option-theoretic), Regime Cross-Sectional (relative), Sentiment SOTP (hybrid), CUCE Ensemble (meta-model), FTNN Topology (neural network), and RCMH-DCF (conditional regime). Currently 9 of 13 are active for this stock. Read the full methodology →

Which valuation models are most bullish and most bearish on PBYI?

Of the 9 models currently active on PBYI, RCMH-DCF is the most bullish at $9.76 per share, and Regime Cross-Sectional is the most bearish at $1.54. CirclFi's published fair value for PBYI is the median of that range, $3.57, not either extreme. The gap between the two ends equals 230% of the median — a wide spread, meaning the methods genuinely disagree and the median should carry less weight. Browse stocks by value-trap risk →

Is PBYI a value trap in 2026?

Puma Biotechnology, Inc.'s Value Trap score is 12/100 (SAFE). This low score indicates the current valuation is not artificially depressed by fundamental deterioration, suggesting genuine opportunity rather than a trap.

Cite this analysis — “According to CirclFi’s 9-model valuation engine, Puma Biotechnology, Inc. (PBYI) has a median fair value of $3.57 — 60.6% below the current price of $9.06 — as of 2026-08-28.” Source: circlfi.com/stock/PBYI/ · Methodology
Primary sources for this PBYI valuation
  • Financial statements: Puma Biotechnology, Inc. 10-K and 10-Q filings on SEC EDGAR (CIK 0001401667) — 700+ standardized XBRL tags, published by the U.S. Securities and Exchange Commission.
  • Discount-rate inputs: FRED, Federal Reserve Bank of St. Louis — risk-free rates, VIX, yield curve, inflation.
  • News sentiment: The GDELT Project — global media tone, input to the Sentiment SOTP model.
  • Model definitions: CirclFi methodology — the published specification for all 13 models, including the academic sources each one implements.

Market data for PBYI as of ; valuations recomputed .

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