Septerna, Inc. (SEPN) Fair Value 2026

SEPN · Biotechnology ·

By CirclFi Research Team · Data from SEC EDGAR, FRED & GDELT

Quality Score

6.3 /10

32 fundamental signals · 3 models active

Value Trap Risk

LOW (25/100)

Quick Summary — As of 2026-08-28, Septerna, Inc. (SEPN) trades at $38.91, versus a $8.96 median fair value across its 3 active models — 77.0% below the current price. QOC: 6.3/10. Value Trap Risk: 25/100 (LOW). 3/13 models active. Within that set, the Bayesian DCF component alone returns $8.40.

Key Facts

Ticker
SEPN
Price
$38.91
Quality Score
6.3/10
Value Trap Risk
25/100
Models Active
3/13
Last Updated
Strength: 3 independent models provide multi-angle coverage
Risk: Majority of models suggest overvaluation

Is Septerna, Inc. (SEPN) Undervalued or Overvalued in 2026?

According to CirclFi’s 3-model valuation engine, Septerna, Inc. (SEPN) appears overvalued as of : the median of 3 independent fair value estimates is $8.96, 77.0% below the current price of $38.91. Estimates range from $8.40 to $18.27. SEPN scores 6.3/10 on fundamental quality and 25/100 on value-trap risk.

For context, the median US equity CirclFi rates trades at an implied -23.4% versus its own 13-model consensus, across 3,809 rated companies as of 2026-08-28. SEPN’s -77.0% gap is wider than that market norm, and the Biotechnology sector median is -64.7%. Full market index →

This verdict compares price to intrinsic value only — it is not a buy or sell rating. For the decision case (bull vs bear arguments, risk factors, peers), read Should You Buy Septerna, Inc. Stock in 2026? →

What Fair Value Does Each Model Give SEPN?

3 Intrinsic Value Models vs. Current Price ($38.91)

Core Models (Unlocked)
Model Fair Value Upside
Intrinsic · High Conviction
 $8.40 -78.4%
Intrinsic · Medium Conviction
 $8.96 -77.0%
Relative · Low Conviction
 $18.27 -53.1%

All Models Active

All 3 models are displayed above.

What Is SEPN's Fair Value Range?

Spread across 3 independent models · $8.40 to $18.27

CirclFi's 3 active models place Septerna, Inc. (SEPN) between $8.40 and $18.27 per share, a spread of 110% of the median. The median of that range — $8.96 — is the fair value CirclFi publishes for SEPN, against a current price of $38.91.

Low · Bayesian DCFHigh · FTNN
$8.40median $8.96$18.27
Where the range comes from
Most bearish modelBayesian DCF$8.40
Most bullish modelFTNN Topology$18.27
Model agreement0 bullish · 3 bearishwide

A band this wide is itself the finding. When independent methods land far apart, they are reading a business whose value depends heavily on which lens you apply — volatile earnings, heavy reinvestment, or an asset base that cash-flow and asset-based methods score differently. That disagreement is information: it says the choice of method matters more than usual for SEPN. Treat the median as one reading among several and compare the individual models below before acting.

Every figure above is one model's standalone output on SEPN, not a CirclFi price target. How each model works →

What Is Septerna, Inc. (SEPN) Worth in 2026?

According to the CirclFi Deep Alpha Valuation Engine, Septerna, Inc.'s intrinsic value is estimated at $8.96. Trading at its current price of $38.91, the valuation engine raises significant caution: 3 of 3 models flag downside risk, projecting a median implied return of -77.0%.

What Do the Models Say About SEPN?

3 of 13 models are currently active for SEPN. All 3 active models suggest the stock trades above fair value. Taken together, their median fair value for SEPN is $8.96 — the figure CirclFi publishes as this stock's fair value. One component of that median, the Bayesian DCF, returns $8.40 on its own, implying -78.4% downside from the current price. See which stocks rank higher →

How Does SEPN Rank in Biotechnology?

Among 625 Biotechnology stocks, SEPN ranks #113 by Quality of Company score. CirclFi's QOC score of 6.3/10 evaluates 32 fundamental signals. A score of 6.3 indicates above-average quality.

See all Most Undervalued Biotechnology Stocks →

Septerna, Inc.'s positioning within the Biotechnology segment means that market exclusivity window plays an outsized role in fundamental analysis. The sector's unique characteristics — including platform technology validation — shape both the opportunity set and risk profile.

Is SEPN a Value Trap?

CirclFi's Value Trap algorithm assigns SEPN a score of 25/100 (LOW). This indicates low risk. The financial profile does not exhibit typical value trap warning signs. The score cross-references apparent undervaluation against fundamental deterioration signals. Browse lowest value-trap stocks →

Multi-Model Methodology

3 of 13 models are active for Septerna, Inc.. Limited activation may indicate insufficient history. Each model applies a fundamentally different valuation philosophy. See the complete methodology →

According to the CirclFi Quality of Company (QOC) framework, Septerna, Inc. earns a quality score of 6.3/10. This respectable rating reflects the company's standing across 32 fundamental signals spanning profitability, growth consistency, balance sheet strength, and capital allocation efficiency.

Models cluster within a tight range (+25.4% spread), increasing conviction. Browse all stocks with 13-model coverage →

Data Sources & Confidence

Every SEPN valuation is built from SEC EDGAR XBRL filings — 700+ standardized financial tags. Macroeconomic context from FRED calibrates discount rates, while GDELT news sentiment feeds into our Sentiment SOTP model. All pipelines run daily. Read the complete data methodology →

Across SEPN's 3 active models, average confidence is 36%. Lower confidence may reflect limited history or high volatility.

CirclFi's output is a research starting point, not a buy/sell signal. All data updates daily. Read the full methodology →

This analysis is produced by the CirclFi Valuation Engine using quantitative models applied to SEC EDGAR filings, public market feeds, and FRED macroeconomic indicators. It is not financial advice.

Read the full investment analysis: Should You Buy Septerna, Inc. Stock in 2026? →

Bull case, bear case, risk factors & peer comparison — updated daily

Which Similar Biotechnology Stocks Should You Also Analyze?

11 related Biotechnology stocks with 13-model coverage

VTGNVistagen Therapeutics, Inc.QOC 6.3RLYBRallybio CorporationQOC 6.3QUREuniQure N.V.QOC 6.3CHRSCoherus Oncology, Inc.QOC 6.3ASMBAssembly Biosciences, Inc.QOC 6.3BRTXBioRestorative Therapies, Inc.QOC 6.3SABSSAB Biotherapeutics, Inc.QOC 5.2BRNSBarinthus Biotherapeutics plcQOC 4.6KLRAKailera Therapeutics, Inc.QOC 3.4EXELExelixis, Inc.QOC 9.6INCYIncyte CorporationQOC 9.5

Read investment analysis: VTGN · RLYB · QURE · CHRS · ASMB · BRTX · SABS · BRNS · KLRA · EXEL · INCY

Which Other Stocks Have a Similar Quality Score to SEPN?

7 companies across all industries closest to SEPN’s Quality of Company score of 6.3/10.

WHLRWheeler Real Estate Investment Trust, Inc.QOC 6.3DOYUDouYu International Holdings LimitedQOC 6.3BKKTBakkt, Inc.QOC 6.3BAXBaxter International Inc.QOC 6.3STRRStar Equity Holdings, Inc.QOC 6.3HCATHealth Catalyst, Inc.QOC 6.3NVDANVIDIA CorporationQOC 10.0

Read investment analysis: WHLR · DOYU · BKKT · BAX · STRR · HCAT · NVDA

Where Does SEPN Sit in CirclFi's Biotechnology Rankings?

SEPN is ranked against every other Biotechnology stock CirclFi covers in each of these screens.

See all Biotechnology stocks ranked →

What Else Do Investors Ask About Septerna, Inc.’s Valuation?

What is Septerna, Inc.'s intrinsic value in 2026?

CirclFi puts Septerna, Inc. (SEPN)'s intrinsic value at $8.96 — the median of 3 independent model estimates as of 2026-08-28, ranging from $8.40 to $18.27. One component of that median, the Bayesian DCF, runs 10,000 Monte Carlo simulations with jump-diffusion and returns $8.40 on its own. The Quality of Company score is 6.3/10 across 32 fundamental signals. All models use SEC EDGAR filings updated daily. See our methodology page for how each model works.

Is SEPN overvalued or undervalued right now?

At $38.91, 0 of 3 active models suggest SEPN may be undervalued, while 3 indicate potential overvaluation. The median of all 3 fair value estimates is $8.96, 77.0% below the current price of $38.91 — a consensus view that SEPN is overvalued. The assessment depends on which methodology best fits Septerna, Inc.'s business model in Biotechnology.

What does a Quality of Company score of 6.3 mean for SEPN?

Septerna, Inc.'s QOC of 6.3/10 reflects 32 fundamental signals: profitability margins, revenue growth consistency, balance sheet leverage, free cash flow generation, and capital allocation efficiency. Scores between 5-7 reflect moderate fundamentals with areas for improvement.

How many valuation models does CirclFi run on SEPN?

CirclFi analyzes SEPN with 13 institutional-grade models daily: Bayesian DCF (Monte Carlo + jump-diffusion), EPV (Greenwald zero-growth), EROIC Spread (McKinsey reinvestment), First Chicago (3-scenario), Markov DDM (regime-switching), ML-RIV (machine learning residual income), Dynamic NAV (asset-based), PWERM (option-theoretic), Regime Cross-Sectional (relative), Sentiment SOTP (hybrid), CUCE Ensemble (meta-model), FTNN Topology (neural network), and RCMH-DCF (conditional regime). Currently 3 of 13 are active for this stock. Read the full methodology →

Which valuation models are most bullish and most bearish on SEPN?

Of the 3 models currently active on SEPN, FTNN Topology is the most bullish at $18.27 per share, and Bayesian DCF is the most bearish at $8.40. CirclFi's published fair value for SEPN is the median of that range, $8.96, not either extreme. The gap between the two ends equals 110% of the median — a wide spread, meaning the methods genuinely disagree and the median should carry less weight. Browse stocks by value-trap risk →

Is SEPN a value trap in 2026?

Septerna, Inc.'s Value Trap score is 25/100 (LOW). This low score indicates the current valuation is not artificially depressed by fundamental deterioration, suggesting genuine opportunity rather than a trap.

Cite this analysis — “According to CirclFi’s 3-model valuation engine, Septerna, Inc. (SEPN) has a median fair value of $8.96 — 77.0% below the current price of $38.91 — as of 2026-08-28.” Source: circlfi.com/stock/SEPN/ · Methodology
Primary sources for this SEPN valuation
  • Financial statements: Septerna, Inc. 10-K and 10-Q filings on SEC EDGAR (CIK 0001984086) — 700+ standardized XBRL tags, published by the U.S. Securities and Exchange Commission.
  • Discount-rate inputs: FRED, Federal Reserve Bank of St. Louis — risk-free rates, VIX, yield curve, inflation.
  • News sentiment: The GDELT Project — global media tone, input to the Sentiment SOTP model.
  • Model definitions: CirclFi methodology — the published specification for all 13 models, including the academic sources each one implements.

Market data for SEPN as of ; valuations recomputed .