Is SEPN or SGP more undervalued in 2026?

CirclFi compares Septerna, Inc. (SEPN) and SpyGlass Pharma, Inc. (SGP) using 13 institutional-grade valuation models. SEPN has a Quality of Company score of 7.0/10 while SGP scores 5.0/10.

Which is a better buy — SEPN or SGP?

Compare intrinsic values from 13 independent models against current market prices. CirclFi also calculates Value Trap scores. This is not financial advice — conduct your own analysis.

How do SEPN and SGP valuations compare?

SEPN at $31.05 and SGP at $19.84 are compared across Bayesian DCF, EPV, EROIC Spread, First Chicago, Markov DDM, and 8 additional models.

SEPN vs SGP Valuation Comparison 2026 — Intrinsic Value Analysis

SEPN

Biotechnology

Septerna, Inc.

Quality

7.0

out of 10

Value Trap

SAFE

Price

$31.05

Last close

Models

10/13

Active

SGP

Biotechnology

SpyGlass Pharma, Inc.

Quality

5.0

out of 10

Value Trap

—

Price

$19.84

Last close

Models

7/13

Active

Model-by-Model Comparison

Model	Type	SEPN Fair Value	SEPN Upside	SGP Fair Value	SGP Upside
Bayesian DCF	Intrinsic	$15.59	-49.8%	$5.82	-70.7%
First Chicago	Scenario	$•••.••	••.•%	$•••.••	••.•%
ML-RIV	Intrinsic	$•••.••	••.•%	$•••.••	••.•%
Dynamic NAV	Asset-Based	$4.39	-85.9%	$2.00	-89.9%
PWERM	Option-Based	$•••.••	••.•%	$•••.••	••.•%
Regime Cross-Sectional	Relative	$•••.••	••.•%	$•••.••	••.•%
Sentiment SOTP	Hybrid	$•••.••	••.•%	$•••.••	••.•%
CUCE Ensemble	Ensemble	$•••.••	••.•%	$•••.••	••.•%
FTNN Topology	Relative	$•••.••	••.•%	$•••.••	••.•%
RCMH-DCF	Intrinsic	$•••.••	••.•%	$•••.••	••.•%

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SEPN vs SGP — Which Stock Is More Undervalued?

SEPN scores higher with a 7.0/10 quality rating vs SGP's 5.0/10. Both stocks are analyzed daily using SEC EDGAR filings across 13 independent models.

Comparing Septerna, Inc. (SEPN) and SpyGlass Pharma, Inc. (SGP) across 13 institutional-grade valuation models reveals how each company's intrinsic value stacks up against its market price. CirclFi's engine processes SEC EDGAR 10-K and 10-Q filings, FRED macroeconomic data, and GDELT news sentiment to generate independent fair value estimates daily.

SEPN currently trades at $31.05 with a QOC of 7.0/10, while SGP trades at $19.84 with a QOC of 5.0/10.

Both companies are analyzed with models spanning intrinsic (Bayesian DCF, EPV), scenario-based (First Chicago), regime-switching (Markov DDM, RCMH-DCF), machine learning (ML-RIV, FTNN Topology), and ensemble methods (CUCE).