Is TVTX or UPB more undervalued in 2026?

CirclFi compares Travere Therapeutics, Inc. (TVTX) and Upstream Bio, Inc. (UPB) using 13 institutional-grade valuation models. TVTX has a Quality of Company score of 6.3/10 while UPB scores 5.9/10.

Which is a better buy — TVTX or UPB?

Compare intrinsic values from 13 independent models against current market prices. CirclFi also calculates Value Trap scores. This is not financial advice — conduct your own analysis.

How do TVTX and UPB valuations compare?

TVTX at $47.76 and UPB at $8.32 are compared across Bayesian DCF, EPV, EROIC Spread, First Chicago, Markov DDM, and 8 additional models.

TVTX vs UPB Valuation Comparison 2026 — Intrinsic Value Analysis

TVTX

Biotechnology

Travere Therapeutics, Inc.

Quality

6.3

out of 10

Value Trap

SAFE

Price

$47.76

Last close

Models

11/13

Active

UPB

Biotechnology

Upstream Bio, Inc.

Quality

5.9

out of 10

Value Trap

SAFE

Price

$8.32

Last close

Models

9/13

Active

Model-by-Model Comparison

Model	Type	TVTX Fair Value	TVTX Upside	UPB Fair Value	UPB Upside
Bayesian DCF	Intrinsic	$12.78	-73.2%	$3.18	-61.8%
Earnings Power Value	Intrinsic	$13.84	-68.6%	—	—
EROIC Spread	Intrinsic	$•••.••	••.•%	$•••.••	••.•%
First Chicago	Scenario	$•••.••	••.•%	$•••.••	••.•%
Markov DDM	Intrinsic	$•••.••	••.•%	$•••.••	••.•%
ML-RIV	Intrinsic	$•••.••	••.•%	$•••.••	••.•%
Dynamic NAV	Asset-Based	—	—	$5.79	-30.4%
PWERM	Option-Based	$•••.••	••.•%	$•••.••	••.•%
Regime Cross-Sectional	Relative	$•••.••	••.•%	$•••.••	••.•%
Sentiment SOTP	Hybrid	$•••.••	••.•%	$•••.••	••.•%
CUCE Ensemble	Ensemble	$•••.••	••.•%	$•••.••	••.•%
FTNN Topology	Relative	$•••.••	••.•%	$•••.••	••.•%

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TVTX vs UPB — Which Stock Is More Undervalued?

TVTX scores higher with a 6.3/10 quality rating vs UPB's 5.9/10. Both stocks are analyzed daily using SEC EDGAR filings across 13 independent models.

Comparing Travere Therapeutics, Inc. (TVTX) and Upstream Bio, Inc. (UPB) across 13 institutional-grade valuation models reveals how each company's intrinsic value stacks up against its market price. CirclFi's engine processes SEC EDGAR 10-K and 10-Q filings, FRED macroeconomic data, and GDELT news sentiment to generate independent fair value estimates daily.

TVTX currently trades at $47.76 with a QOC of 6.3/10, while UPB trades at $8.32 with a QOC of 5.9/10.

Both companies are analyzed with models spanning intrinsic (Bayesian DCF, EPV), scenario-based (First Chicago), regime-switching (Markov DDM, RCMH-DCF), machine learning (ML-RIV, FTNN Topology), and ensemble methods (CUCE).