Is SPRO or SRPT more undervalued in 2026?

CirclFi compares Spero Therapeutics, Inc. (SPRO) and Sarepta Therapeutics, Inc. (SRPT) using 13 institutional-grade valuation models. SPRO has a Quality of Company score of 7.4/10 while SRPT scores 7.5/10.

Which is a better buy — SPRO or SRPT?

Compare intrinsic values from 13 independent models against current market prices. CirclFi also calculates Value Trap scores. This is not financial advice — conduct your own analysis.

How do SPRO and SRPT valuations compare?

SPRO at $2.83 and SRPT at $17.87 are compared across Bayesian DCF, EPV, EROIC Spread, First Chicago, Markov DDM, and 8 additional models.

SPRO vs SRPT Valuation Comparison 2026 — Intrinsic Value Analysis

SPRO

Pharmaceutical Preparations

Spero Therapeutics, Inc.

Quality

7.4

out of 10

Value Trap

WARN

Price

$2.83

Last close

Models

10/13

Active

SRPT

Pharmaceutical Preparations

Sarepta Therapeutics, Inc.

Quality

7.5

out of 10

Value Trap

SAFE

Price

$17.87

Last close

Models

13/13

Active

Model-by-Model Comparison

Model	Type	SPRO Fair Value	SPRO Upside	SRPT Fair Value	SRPT Upside
Bayesian DCF	Intrinsic	$1.22	-57.0%	$1.07	-94.0%
Earnings Power Value	Intrinsic	—	—	$4.59	-77.4%
EROIC Spread	Intrinsic	$•••.••	••.•%	$•••.••	••.•%
First Chicago	Scenario	$•••.••	••.•%	$•••.••	••.•%
Markov DDM	Intrinsic	$•••.••	••.•%	$•••.••	••.•%
ML-RIV	Intrinsic	$•••.••	••.•%	$•••.••	••.•%
Dynamic NAV	Asset-Based	$1.96	-30.6%	$14.45	-19.1%
PWERM	Option-Based	$•••.••	••.•%	$•••.••	••.•%
Regime Cross-Sectional	Relative	$•••.••	••.•%	$•••.••	••.•%
Sentiment SOTP	Hybrid	$•••.••	••.•%	$•••.••	••.•%
CUCE Ensemble	Ensemble	$•••.••	••.•%	$•••.••	••.•%
FTNN Topology	Relative	$•••.••	••.•%	$•••.••	••.•%
RCMH-DCF	Intrinsic	$•••.••	••.•%	$•••.••	••.•%

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SPRO vs SRPT — Which Stock Is More Undervalued?

SRPT scores higher with a 7.5/10 quality rating vs SPRO's 7.4/10. Both stocks are analyzed daily using SEC EDGAR filings across 13 independent models.

Comparing Spero Therapeutics, Inc. (SPRO) and Sarepta Therapeutics, Inc. (SRPT) across 13 institutional-grade valuation models reveals how each company's intrinsic value stacks up against its market price. CirclFi's engine processes SEC EDGAR 10-K and 10-Q filings, FRED macroeconomic data, and GDELT news sentiment to generate independent fair value estimates daily.

SPRO currently trades at $2.83 with a QOC of 7.4/10, while SRPT trades at $17.87 with a QOC of 7.5/10.

Both companies are analyzed with models spanning intrinsic (Bayesian DCF, EPV), scenario-based (First Chicago), regime-switching (Markov DDM, RCMH-DCF), machine learning (ML-RIV, FTNN Topology), and ensemble methods (CUCE).