Is SHPH or SUPN more undervalued in 2026?

CirclFi compares Shuttle Pharmaceuticals Holding (SHPH) and Supernus Pharmaceuticals, Inc. (SUPN) using 13 institutional-grade valuation models. SHPH has a Quality of Company score of 3.6/10 while SUPN scores 7.8/10.

Which is a better buy — SHPH or SUPN?

Compare intrinsic values from 13 independent models against current market prices. CirclFi also calculates Value Trap scores. This is not financial advice — conduct your own analysis.

How do SHPH and SUPN valuations compare?

SHPH at $0.54 and SUPN at $46.85 are compared across Bayesian DCF, EPV, EROIC Spread, First Chicago, Markov DDM, and 8 additional models.

SHPH vs SUPN Valuation Comparison 2026 — Intrinsic Value Analysis

SHPH

Drug Manufacturers - Specialty & Generic

Shuttle Pharmaceuticals Holding

Quality

3.6

out of 10

Value Trap

SAFE

Price

$0.54

Last close

Models

8/13

Active

SUPN

Drug Manufacturers - Specialty & Generic

Supernus Pharmaceuticals, Inc.

Quality

7.8

out of 10

Value Trap

LOW

Price

$46.85

Last close

Models

13/13

Active

Model-by-Model Comparison

Model	Type	SHPH Fair Value	SHPH Upside	SUPN Fair Value	SUPN Upside
Bayesian DCF	Intrinsic	$3.22	+464.6%	$17.17	-63.4%
Earnings Power Value	Intrinsic	—	—	$16.57	-64.6%
EROIC Spread	Intrinsic	$•••.••	••.•%	$•••.••	••.•%
First Chicago	Scenario	$•••.••	••.•%	$•••.••	••.•%
Markov DDM	Intrinsic	$•••.••	••.•%	$•••.••	••.•%
ML-RIV	Intrinsic	$0.08	-88.0%	$10.70	-77.2%
Dynamic NAV	Asset-Based	$•••.••	••.•%	$•••.••	••.•%
PWERM	Option-Based	$•••.••	••.•%	$•••.••	••.•%
Regime Cross-Sectional	Relative	$•••.••	••.•%	$•••.••	••.•%
Sentiment SOTP	Hybrid	$•••.••	••.•%	$•••.••	••.•%
CUCE Ensemble	Ensemble	$•••.••	••.•%	$•••.••	••.•%
FTNN Topology	Relative	$•••.••	••.•%	$•••.••	••.•%
RCMH-DCF	Intrinsic	$•••.••	••.•%	$•••.••	••.•%

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SHPH vs SUPN — Which Stock Is More Undervalued?

SUPN scores higher with a 7.8/10 quality rating vs SHPH's 3.6/10. Both stocks are analyzed daily using SEC EDGAR filings across 13 independent models.

Comparing Shuttle Pharmaceuticals Holding (SHPH) and Supernus Pharmaceuticals, Inc. (SUPN) across 13 institutional-grade valuation models reveals how each company's intrinsic value stacks up against its market price. CirclFi's engine processes SEC EDGAR 10-K and 10-Q filings, FRED macroeconomic data, and GDELT news sentiment to generate independent fair value estimates daily.

SHPH currently trades at $0.54 with a QOC of 3.6/10, while SUPN trades at $46.85 with a QOC of 7.8/10.

Both companies are analyzed with models spanning intrinsic (Bayesian DCF, EPV), scenario-based (First Chicago), regime-switching (Markov DDM, RCMH-DCF), machine learning (ML-RIV, FTNN Topology), and ensemble methods (CUCE).