Is SGP or SION more undervalued in 2026?

CirclFi compares SpyGlass Pharma, Inc. (SGP) and Sionna Therapeutics, Inc. (SION) using 13 institutional-grade valuation models. SGP has a Quality of Company score of 5.0/10 while SION scores 4.3/10.

Which is a better buy — SGP or SION?

Compare intrinsic values from 13 independent models against current market prices. CirclFi also calculates Value Trap scores. This is not financial advice — conduct your own analysis.

How do SGP and SION valuations compare?

SGP at $19.84 and SION at $42.80 are compared across Bayesian DCF, EPV, EROIC Spread, First Chicago, Markov DDM, and 8 additional models.

SGP vs SION Valuation Comparison 2026 — Intrinsic Value Analysis

SGP

Biotechnology

SpyGlass Pharma, Inc.

Quality

5.0

out of 10

Value Trap

—

Price

$19.84

Last close

Models

7/13

Active

SION

Biotechnology

Sionna Therapeutics, Inc.

Quality

4.3

out of 10

Value Trap

—

Price

$42.80

Last close

Models

10/13

Active

Model-by-Model Comparison

Model	Type	SGP Fair Value	SGP Upside	SION Fair Value	SION Upside
Bayesian DCF	Intrinsic	$5.82	-70.7%	$8.06	-81.2%
Earnings Power Value	Intrinsic	—	—	$15.97	-58.1%
EROIC Spread	Intrinsic	$•••.••	••.•%	$•••.••	••.•%
First Chicago	Scenario	$•••.••	••.•%	$•••.••	••.•%
Markov DDM	Intrinsic	$•••.••	••.•%	$•••.••	••.•%
ML-RIV	Intrinsic	$•••.••	••.•%	$•••.••	••.•%
Dynamic NAV	Asset-Based	$2.00	-89.9%	$4.47	-88.6%
PWERM	Option-Based	$•••.••	••.•%	$•••.••	••.•%
Sentiment SOTP	Hybrid	$•••.••	••.•%	$•••.••	••.•%
CUCE Ensemble	Ensemble	$•••.••	••.•%	$•••.••	••.•%

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SGP vs SION — Which Stock Is More Undervalued?

SGP scores higher with a 5.0/10 quality rating vs SION's 4.3/10. Both stocks are analyzed daily using SEC EDGAR filings across 13 independent models.

Comparing SpyGlass Pharma, Inc. (SGP) and Sionna Therapeutics, Inc. (SION) across 13 institutional-grade valuation models reveals how each company's intrinsic value stacks up against its market price. CirclFi's engine processes SEC EDGAR 10-K and 10-Q filings, FRED macroeconomic data, and GDELT news sentiment to generate independent fair value estimates daily.

SGP currently trades at $19.84 with a QOC of 5.0/10, while SION trades at $42.80 with a QOC of 4.3/10.

Both companies are analyzed with models spanning intrinsic (Bayesian DCF, EPV), scenario-based (First Chicago), regime-switching (Markov DDM, RCMH-DCF), machine learning (ML-RIV, FTNN Topology), and ensemble methods (CUCE).