Is OPK or ORKA more undervalued in 2026?

CirclFi compares Opko Health, Inc. (OPK) and Oruka Therapeutics, Inc. (ORKA) using 13 institutional-grade valuation models. OPK has a Quality of Company score of 5.9/10 while ORKA scores 4.3/10.

Which is a better buy — OPK or ORKA?

Compare intrinsic values from 13 independent models against current market prices. CirclFi also calculates Value Trap scores. This is not financial advice — conduct your own analysis.

How do OPK and ORKA valuations compare?

OPK at $1.46 and ORKA at $58.53 are compared across Bayesian DCF, EPV, EROIC Spread, First Chicago, Markov DDM, and 8 additional models.

OPK vs ORKA Valuation Comparison 2026 — Intrinsic Value Analysis

OPK

Pharmaceutical Preparations

Opko Health, Inc.

Quality

5.9

out of 10

Value Trap

LOW

Price

$1.46

Last close

Models

12/13

Active

ORKA

Pharmaceutical Preparations

Oruka Therapeutics, Inc.

Quality

4.3

out of 10

Value Trap

SAFE

Price

$58.53

Last close

Models

10/13

Active

Model-by-Model Comparison

Model	Type	OPK Fair Value	OPK Upside	ORKA Fair Value	ORKA Upside
Bayesian DCF	Intrinsic	$0.22	-84.8%	$18.48	-68.4%
Earnings Power Value	Intrinsic	$0.04	-96.8%	$31.09	-55.0%
EROIC Spread	Intrinsic	$•••.••	••.•%	$•••.••	••.•%
First Chicago	Scenario	$•••.••	••.•%	$•••.••	••.•%
Markov DDM	Intrinsic	$•••.••	••.•%	$•••.••	••.•%
ML-RIV	Intrinsic	$•••.••	••.•%	$•••.••	••.•%
Dynamic NAV	Asset-Based	$•••.••	••.•%	$•••.••	••.•%
PWERM	Option-Based	$•••.••	••.•%	$•••.••	••.•%
Regime Cross-Sectional	Relative	$•••.••	••.•%	$•••.••	••.•%
Sentiment SOTP	Hybrid	$•••.••	••.•%	$•••.••	••.•%
CUCE Ensemble	Ensemble	$•••.••	••.•%	$•••.••	••.•%
FTNN Topology	Relative	$•••.••	••.•%	$•••.••	••.•%

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OPK vs ORKA — Which Stock Is More Undervalued?

OPK scores higher with a 5.9/10 quality rating vs ORKA's 4.3/10. Both stocks are analyzed daily using SEC EDGAR filings across 13 independent models.

Comparing Opko Health, Inc. (OPK) and Oruka Therapeutics, Inc. (ORKA) across 13 institutional-grade valuation models reveals how each company's intrinsic value stacks up against its market price. CirclFi's engine processes SEC EDGAR 10-K and 10-Q filings, FRED macroeconomic data, and GDELT news sentiment to generate independent fair value estimates daily.

OPK currently trades at $1.46 with a QOC of 5.9/10, while ORKA trades at $58.53 with a QOC of 4.3/10.

Both companies are analyzed with models spanning intrinsic (Bayesian DCF, EPV), scenario-based (First Chicago), regime-switching (Markov DDM, RCMH-DCF), machine learning (ML-RIV, FTNN Topology), and ensemble methods (CUCE).