Is GUTS or GYRE more undervalued in 2026?

CirclFi compares Fractyl Health, Inc. (GUTS) and Gyre Therapeutics, Inc. (GYRE) using 13 institutional-grade valuation models. GUTS has a Quality of Company score of 4.4/10 while GYRE scores 8.0/10.

Which is a better buy — GUTS or GYRE?

Compare intrinsic values from 13 independent models against current market prices. CirclFi also calculates Value Trap scores. This is not financial advice — conduct your own analysis.

How do GUTS and GYRE valuations compare?

GUTS at $0.84 and GYRE at $5.74 are compared across Bayesian DCF, EPV, EROIC Spread, First Chicago, Markov DDM, and 8 additional models.

GUTS vs GYRE Valuation Comparison 2026 — Intrinsic Value Analysis

GUTS

Biotechnology

Fractyl Health, Inc.

Quality

4.4

out of 10

Value Trap

SAFE

Price

$0.84

Last close

Models

9/13

Active

GYRE

Biotechnology

Gyre Therapeutics, Inc.

Quality

8.0

out of 10

Value Trap

SAFE

Price

$5.74

Last close

Models

12/13

Active

Model-by-Model Comparison

Model	Type	GUTS Fair Value	GUTS Upside	GYRE Fair Value	GYRE Upside
Bayesian DCF	Intrinsic	$0.28	-66.8%	$0.52	-90.9%
Earnings Power Value	Intrinsic	$0.47	-32.7%	$0.74	-87.1%
EROIC Spread	Intrinsic	$•••.••	••.•%	$•••.••	••.•%
First Chicago	Scenario	$•••.••	••.•%	$•••.••	••.•%
ML-RIV	Intrinsic	$•••.••	••.•%	$•••.••	••.•%
Dynamic NAV	Asset-Based	$•••.••	••.•%	$•••.••	••.•%
PWERM	Option-Based	$•••.••	••.•%	$•••.••	••.•%
Regime Cross-Sectional	Relative	$•••.••	••.•%	$•••.••	••.•%
Sentiment SOTP	Hybrid	$•••.••	••.•%	$•••.••	••.•%
CUCE Ensemble	Ensemble	$•••.••	••.•%	$•••.••	••.•%
FTNN Topology	Relative	$•••.••	••.•%	$•••.••	••.•%
RCMH-DCF	Intrinsic	$•••.••	••.•%	$•••.••	••.•%

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GUTS vs GYRE — Which Stock Is More Undervalued?

GYRE scores higher with a 8.0/10 quality rating vs GUTS's 4.4/10. Both stocks are analyzed daily using SEC EDGAR filings across 13 independent models.

Comparing Fractyl Health, Inc. (GUTS) and Gyre Therapeutics, Inc. (GYRE) across 13 institutional-grade valuation models reveals how each company's intrinsic value stacks up against its market price. CirclFi's engine processes SEC EDGAR 10-K and 10-Q filings, FRED macroeconomic data, and GDELT news sentiment to generate independent fair value estimates daily.

GUTS currently trades at $0.84 with a QOC of 4.4/10, while GYRE trades at $5.74 with a QOC of 8.0/10.

Both companies are analyzed with models spanning intrinsic (Bayesian DCF, EPV), scenario-based (First Chicago), regime-switching (Markov DDM, RCMH-DCF), machine learning (ML-RIV, FTNN Topology), and ensemble methods (CUCE).