ANRO vs APVO

Alto Neuroscience, Inc. vs Aptevo Therapeutics Inc. — Valuation Comparison 2026

By CirclFi Research Team · Updated 2026-06-03 · Data from SEC EDGAR, FRED & GDELT

Quick Summary — ANRO scores higher on quality with 4.7/10 vs APVO's 4.2/10. ANRO trades at $18.71 while APVO trades at $5.04. Both analyzed daily using SEC EDGAR data across 13 institutional models.

ANRO

Biotechnology
Alto Neuroscience, Inc.
Quality
4.7
out of 10
Value Trap
12
SAFE
Price
$18.71
Last close
Models
7/13
Active
VS

APVO

Biotechnology
Aptevo Therapeutics Inc.
Quality
4.2
out of 10
Value Trap
24
SAFE
Price
$5.04
Last close
Models
6/13
Active
ANRO
2 models active
Quality 4.7/10 — below average
APVO
Bayesian DCF sees +21.0% upside
Quality 4.2/10 — below average

ANRO vs APVO — Fair Value Comparison

ANRO
$0$7$15$22 Price$18.71 Bayesian …$6.57 (-64.9%) ML-RIV$2.15 (-88.5%)
APVO
$0$2$5$7 Price$5.04 Bayesian …$6.10 (+21.0%) ML-RIV$0.36 (-92.6%)
Market Price Model 1 Model 2

Model-by-Model Comparison

ModelType ANRO Fair ValueANRO Upside APVO Fair ValueAPVO Upside
Bayesian DCF Intrinsic $6.57 -64.9% $6.10 +21.0%
First Chicago Scenario $•••.•• ••.•% $•••.•• ••.•%
ML-RIV Intrinsic $2.15 -88.5% $0.36 -92.6%
Dynamic NAV Asset-Based $•••.•• ••.•% $•••.•• ••.•%
PWERM Option-Based $•••.•• ••.•% $•••.•• ••.•%
Sentiment SOTP Hybrid $•••.•• ••.•% $•••.•• ••.•%
CUCE Ensemble Ensemble $•••.•• ••.•% $•••.•• ••.•%

ANRO vs APVO — Which Stock Is More Undervalued in 2026?

ANRO scores higher with a 4.7/10 quality rating vs APVO's 4.2/10. Both stocks are analyzed daily using SEC EDGAR filings across 13 independent models.

How Do ANRO and APVO Valuations Compare?

At $18.71, ANRO trades +64.9% above its Bayesian DCF fair value of $6.57, while APVO at $5.04 trades +21.0% below its estimate of $6.10. ANRO shows a wider gap between price and intrinsic value.

Quality of Company: ANRO vs APVO

ANRO earns a Quality of Company score of 4.7/10 compared to APVO's 4.2/10. The scores are closely matched, indicating similar fundamental quality profiles. The QOC score synthesizes 32 signals spanning profitability margins, revenue growth, free cash flow, capital allocation, and leverage.

Value Trap Risk: ANRO vs APVO

ANRO carries a SAFE value trap risk (12/100) while APVO shows SAFE risk (24/100). Both companies show manageable value trap risk, suggesting their current valuations are not artificially depressed by fundamental deterioration.

Both in Biotechnology

Both ANRO and APVO operate in Biotechnology, which has 566 stocks tracked by CirclFi. Same-industry comparisons provide the most direct insight into relative valuation since both companies face similar regulatory environments, market dynamics, and competitive pressures. Both companies are analyzed with models spanning intrinsic (Bayesian DCF, EPV), scenario-based (First Chicago), regime-switching (Markov DDM, RCMH-DCF), machine learning (ML-RIV, FTNN), and ensemble methods (CUCE).

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