Is AGEN or AGIO more undervalued in 2026?

CirclFi compares Agenus Inc. (AGEN) and Agios Pharmaceuticals, Inc. (AGIO) using 13 institutional-grade valuation models. AGEN has a Quality of Company score of 4.8/10 while AGIO scores 6.0/10.

Which is a better buy — AGEN or AGIO?

Compare intrinsic values from 13 independent models against current market prices. CirclFi also calculates Value Trap scores. This is not financial advice — conduct your own analysis.

How do AGEN and AGIO valuations compare?

AGEN at $3.40 and AGIO at $30.42 are compared across Bayesian DCF, EPV, EROIC Spread, First Chicago, Markov DDM, and 8 additional models.

AGEN vs AGIO Valuation Comparison 2026 — Intrinsic Value Analysis

AGEN

Biotechnology

Agenus Inc.

Quality

4.8

out of 10

Value Trap

WARN

Price

$3.40

Last close

Models

12/13

Active

AGIO

Biotechnology

Agios Pharmaceuticals, Inc.

Quality

6.0

out of 10

Value Trap

SAFE

Price

$30.42

Last close

Models

12/13

Active

Model-by-Model Comparison

Model	Type	AGEN Fair Value	AGEN Upside	AGIO Fair Value	AGIO Upside
Bayesian DCF	Intrinsic	$11.25	+230.8%	$8.83	-71.0%
Earnings Power Value	Intrinsic	$2.25	-33.7%	$3.81	-86.5%
EROIC Spread	Intrinsic	$•••.••	••.•%	$•••.••	••.•%
First Chicago	Scenario	$•••.••	••.•%	$•••.••	••.•%
Markov DDM	Intrinsic	$•••.••	••.•%	$•••.••	••.•%
ML-RIV	Intrinsic	$•••.••	••.•%	$•••.••	••.•%
Dynamic NAV	Asset-Based	$•••.••	••.•%	$•••.••	••.•%
PWERM	Option-Based	$•••.••	••.•%	$•••.••	••.•%
Regime Cross-Sectional	Relative	$•••.••	••.•%	$•••.••	••.•%
Sentiment SOTP	Hybrid	$•••.••	••.•%	$•••.••	••.•%
CUCE Ensemble	Ensemble	$•••.••	••.•%	$•••.••	••.•%
FTNN Topology	Relative	$•••.••	••.•%	$•••.••	••.•%
RCMH-DCF	Intrinsic	$•••.••	••.•%	$•••.••	••.•%

🔒

Unlock Full 13-Model Comparison

Access all valuation models for AGEN vs AGIO — including EROIC Spread, First Chicago, Markov DDM, PWERM, and 7 more.

Access Full Analysis — From $27/mo →

AGEN vs AGIO — Which Stock Is More Undervalued?

AGIO scores higher with a 6.0/10 quality rating vs AGEN's 4.8/10. Both stocks are analyzed daily using SEC EDGAR filings across 13 independent models.

Comparing Agenus Inc. (AGEN) and Agios Pharmaceuticals, Inc. (AGIO) across 13 institutional-grade valuation models reveals how each company's intrinsic value stacks up against its market price. CirclFi's engine processes SEC EDGAR 10-K and 10-Q filings, FRED macroeconomic data, and GDELT news sentiment to generate independent fair value estimates daily.

AGEN currently trades at $3.40 with a QOC of 4.8/10, while AGIO trades at $30.42 with a QOC of 6.0/10.

Both companies are analyzed with models spanning intrinsic (Bayesian DCF, EPV), scenario-based (First Chicago), regime-switching (Markov DDM, RCMH-DCF), machine learning (ML-RIV, FTNN Topology), and ensemble methods (CUCE).