Is XLO or XRTX more undervalued in 2026?

CirclFi compares Xilio Therapeutics, Inc. (XLO) and XORTX Therapeutics Inc. (XRTX) using 13 institutional-grade valuation models. XLO has a Quality of Company score of 5.2/10 while XRTX scores 3.4/10.

Which is a better buy — XLO or XRTX?

Compare intrinsic values from 13 independent models against current market prices. CirclFi also calculates Value Trap scores. This is not financial advice — conduct your own analysis.

How do XLO and XRTX valuations compare?

XLO at $8.52 and XRTX at $2.26 are compared across Bayesian DCF, EPV, EROIC Spread, First Chicago, Markov DDM, and 8 additional models.

XLO vs XRTX Valuation Comparison 2026 — Intrinsic Value Analysis

XLO

Biotechnology

Xilio Therapeutics, Inc.

Quality

5.2

out of 10

Value Trap

LOW

Price

$8.52

Last close

Models

9/13

Active

XRTX

Biotechnology

XORTX Therapeutics Inc.

Quality

3.4

out of 10

Value Trap

—

Price

$2.26

Last close

Models

7/13

Active

Model-by-Model Comparison

Model	Type	XLO Fair Value	XLO Upside	XRTX Fair Value	XRTX Upside
Bayesian DCF	Intrinsic	$15.59	+83.0%	$4.91	+117.4%
First Chicago	Scenario	$•••.••	••.•%	$•••.••	••.•%
ML-RIV	Intrinsic	$1.06	-87.7%	$4.24	+87.4%
Dynamic NAV	Asset-Based	$24.89	+192.1%	$6.57	+190.8%
PWERM	Option-Based	$•••.••	••.•%	$•••.••	••.•%
Regime Cross-Sectional	Relative	$•••.••	••.•%	$•••.••	••.•%
Sentiment SOTP	Hybrid	$•••.••	••.•%	$•••.••	••.•%
CUCE Ensemble	Ensemble	$•••.••	••.•%	$•••.••	••.•%
FTNN Topology	Relative	$•••.••	••.•%	$•••.••	••.•%

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XLO vs XRTX — Which Stock Is More Undervalued?

XLO scores higher with a 5.2/10 quality rating vs XRTX's 3.4/10. Both stocks are analyzed daily using SEC EDGAR filings across 13 independent models.

Comparing Xilio Therapeutics, Inc. (XLO) and XORTX Therapeutics Inc. (XRTX) across 13 institutional-grade valuation models reveals how each company's intrinsic value stacks up against its market price. CirclFi's engine processes SEC EDGAR 10-K and 10-Q filings, FRED macroeconomic data, and GDELT news sentiment to generate independent fair value estimates daily.

XLO currently trades at $8.52 with a QOC of 5.2/10, while XRTX trades at $2.26 with a QOC of 3.4/10.

Both companies are analyzed with models spanning intrinsic (Bayesian DCF, EPV), scenario-based (First Chicago), regime-switching (Markov DDM, RCMH-DCF), machine learning (ML-RIV, FTNN Topology), and ensemble methods (CUCE).