Is TLSA or TPST more undervalued in 2026?

CirclFi compares Tiziana Life Sciences Ltd (TLSA) and Tempest Therapeutics, Inc. (TPST) using 13 institutional-grade valuation models. TLSA has a Quality of Company score of 1.7/10 while TPST scores 3.2/10.

Which is a better buy — TLSA or TPST?

Compare intrinsic values from 13 independent models against current market prices. CirclFi also calculates Value Trap scores. This is not financial advice — conduct your own analysis.

How do TLSA and TPST valuations compare?

TLSA at $1.46 and TPST at $1.73 are compared across Bayesian DCF, EPV, EROIC Spread, First Chicago, Markov DDM, and 8 additional models.

TLSA vs TPST Valuation Comparison 2026 — Intrinsic Value Analysis

TLSA

Biotechnology

Tiziana Life Sciences Ltd

Quality

1.7

out of 10

Value Trap

—

Price

$1.46

Last close

Models

7/13

Active

TPST

Biotechnology

Tempest Therapeutics, Inc.

Quality

3.2

out of 10

Value Trap

LOW

Price

$1.73

Last close

Models

7/13

Active

Model-by-Model Comparison

Model	Type	TLSA Fair Value	TLSA Upside	TPST Fair Value	TPST Upside
Bayesian DCF	Intrinsic	$0.39	-73.5%	$0.32	-81.3%
First Chicago	Scenario	$•••.••	••.•%	$•••.••	••.•%
ML-RIV	Intrinsic	$•••.••	••.•%	$•••.••	••.•%
Dynamic NAV	Asset-Based	$0.04	-97.4%	$5.58	+222.6%
PWERM	Option-Based	$1.41	-3.8%	$1.92	+11.3%
Sentiment SOTP	Hybrid	$•••.••	••.•%	$•••.••	••.•%
CUCE Ensemble	Ensemble	$•••.••	••.•%	$•••.••	••.•%

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TLSA vs TPST — Which Stock Is More Undervalued?

TPST scores higher with a 3.2/10 quality rating vs TLSA's 1.7/10. Both stocks are analyzed daily using SEC EDGAR filings across 13 independent models.

Comparing Tiziana Life Sciences Ltd (TLSA) and Tempest Therapeutics, Inc. (TPST) across 13 institutional-grade valuation models reveals how each company's intrinsic value stacks up against its market price. CirclFi's engine processes SEC EDGAR 10-K and 10-Q filings, FRED macroeconomic data, and GDELT news sentiment to generate independent fair value estimates daily.

TLSA currently trades at $1.46 with a QOC of 1.7/10, while TPST trades at $1.73 with a QOC of 3.2/10.

Both companies are analyzed with models spanning intrinsic (Bayesian DCF, EPV), scenario-based (First Chicago), regime-switching (Markov DDM, RCMH-DCF), machine learning (ML-RIV, FTNN Topology), and ensemble methods (CUCE).