Is STTK or SYRE more undervalued in 2026?

CirclFi compares Shattuck Labs, Inc. (STTK) and Spyre Therapeutics, Inc. (SYRE) using 13 institutional-grade valuation models. STTK has a Quality of Company score of 5.8/10 while SYRE scores 5.4/10.

Which is a better buy — STTK or SYRE?

Compare intrinsic values from 13 independent models against current market prices. CirclFi also calculates Value Trap scores. This is not financial advice — conduct your own analysis.

How do STTK and SYRE valuations compare?

STTK at $5.97 and SYRE at $72.11 are compared across Bayesian DCF, EPV, EROIC Spread, First Chicago, Markov DDM, and 8 additional models.

STTK vs SYRE Valuation Comparison 2026 — Intrinsic Value Analysis

STTK

Biotechnology

Shattuck Labs, Inc.

Quality

5.8

out of 10

Value Trap

SAFE

Price

$5.97

Last close

Models

9/13

Active

SYRE

Biotechnology

Spyre Therapeutics, Inc.

Quality

5.4

out of 10

Value Trap

SAFE

Price

$72.11

Last close

Models

12/13

Active

Model-by-Model Comparison

Model	Type	STTK Fair Value	STTK Upside	SYRE Fair Value	SYRE Upside
Bayesian DCF	Intrinsic	$2.24	-62.5%	$22.23	-69.2%
Earnings Power Value	Intrinsic	—	—	$30.32	-56.5%
EROIC Spread	Intrinsic	$•••.••	••.•%	$•••.••	••.•%
First Chicago	Scenario	$•••.••	••.•%	$•••.••	••.•%
Markov DDM	Intrinsic	$•••.••	••.•%	$•••.••	••.•%
ML-RIV	Intrinsic	$•••.••	••.•%	$•••.••	••.•%
Dynamic NAV	Asset-Based	$1.97	-66.9%	$5.82	-91.9%
PWERM	Option-Based	$•••.••	••.•%	$•••.••	••.•%
Regime Cross-Sectional	Relative	$•••.••	••.•%	$•••.••	••.•%
Sentiment SOTP	Hybrid	$•••.••	••.•%	$•••.••	••.•%
CUCE Ensemble	Ensemble	$•••.••	••.•%	$•••.••	••.•%
FTNN Topology	Relative	$•••.••	••.•%	$•••.••	••.•%

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STTK vs SYRE — Which Stock Is More Undervalued?

STTK scores higher with a 5.8/10 quality rating vs SYRE's 5.4/10. Both stocks are analyzed daily using SEC EDGAR filings across 13 independent models.

Comparing Shattuck Labs, Inc. (STTK) and Spyre Therapeutics, Inc. (SYRE) across 13 institutional-grade valuation models reveals how each company's intrinsic value stacks up against its market price. CirclFi's engine processes SEC EDGAR 10-K and 10-Q filings, FRED macroeconomic data, and GDELT news sentiment to generate independent fair value estimates daily.

STTK currently trades at $5.97 with a QOC of 5.8/10, while SYRE trades at $72.11 with a QOC of 5.4/10.

Both companies are analyzed with models spanning intrinsic (Bayesian DCF, EPV), scenario-based (First Chicago), regime-switching (Markov DDM, RCMH-DCF), machine learning (ML-RIV, FTNN Topology), and ensemble methods (CUCE).