SPRO vs SRRK

Spero Therapeutics, Inc. vs Scholar Rock Holding Corporatio — Valuation Comparison 2026

By CirclFi Research Team · Updated 2026-06-03 · Data from SEC EDGAR, FRED & GDELT

Quick Summary — SPRO scores higher on quality with 7.5/10 vs SRRK's 5.1/10. SPRO trades at $2.83 while SRRK trades at $44.68. Both analyzed daily using SEC EDGAR data across 13 institutional models.

SPRO

Biotechnology
Spero Therapeutics, Inc.
Quality
7.5
out of 10
Value Trap
48
WARN
Price
$2.83
Last close
Models
10/13
Active
VS

SRRK

Biotechnology
Scholar Rock Holding Corporatio
Quality
5.1
out of 10
Value Trap
30
LOW
Price
$44.68
Last close
Models
10/13
Active
SPRO
2 models active
Value Trap 48/100 — caution
SRRK
2 models active
Limited to 2/13 visible models

SPRO vs SRRK — Fair Value Comparison

SPRO
$0$1$2$3 Price$2.83 Bayesian …$1.25 (-55.9%) Dynamic N…$1.96 (-30.6%)
SRRK
$0$18$35$53 Price$44.68 Bayesian …$14.50 (-67.6%) Earnings …$21.36 (-54.0%)
Market Price Model 1 Model 2

Model-by-Model Comparison

ModelType SPRO Fair ValueSPRO Upside SRRK Fair ValueSRRK Upside
Bayesian DCF Intrinsic $1.25 -55.9% $14.50 -67.6%
Earnings Power Value Intrinsic $21.36 -54.0%
EROIC Spread Intrinsic $•••.•• ••.•% $•••.•• ••.•%
First Chicago Scenario $•••.•• ••.•% $•••.•• ••.•%
Markov DDM Intrinsic $•••.•• ••.•% $•••.•• ••.•%
ML-RIV Intrinsic $•••.•• ••.•% $•••.•• ••.•%
Dynamic NAV Asset-Based $1.96 -30.6% $4.25 -90.5%
PWERM Option-Based $•••.•• ••.•% $•••.•• ••.•%
Regime Cross-Sectional Relative $•••.•• ••.•% $•••.•• ••.•%
Sentiment SOTP Hybrid $•••.•• ••.•% $•••.•• ••.•%
CUCE Ensemble Ensemble $•••.•• ••.•% $•••.•• ••.•%
FTNN Topology Relative $•••.•• ••.•% $•••.•• ••.•%
RCMH-DCF Intrinsic $•••.•• ••.•% $•••.•• ••.•%

SPRO vs SRRK — Which Stock Is More Undervalued in 2026?

SPRO scores higher with a 7.5/10 quality rating vs SRRK's 5.1/10. Both stocks are analyzed daily using SEC EDGAR filings across 13 independent models.

How Do SPRO and SRRK Valuations Compare?

At $2.83, SPRO trades +55.9% above its Bayesian DCF fair value of $1.25, while SRRK at $44.68 trades +67.6% above its estimate of $14.50. SRRK shows a wider gap between price and intrinsic value.

Quality of Company: SPRO vs SRRK

SPRO earns a Quality of Company score of 7.5/10 compared to SRRK's 5.1/10. This moderate difference suggests one company has an edge in fundamental quality, though both may offer investment merit depending on valuation. The QOC score synthesizes 32 signals spanning profitability margins, revenue growth, free cash flow, capital allocation, and leverage.

Value Trap Risk: SPRO vs SRRK

SPRO carries a WARN value trap risk (48/100) while SRRK shows LOW risk (30/100). Stocks with value trap scores above 40 may appear undervalued but face deteriorating fundamentals — declining margins, rising debt, or shrinking revenue can make the apparent discount a trap.

Both in Biotechnology

Both SPRO and SRRK operate in Biotechnology, which has 566 stocks tracked by CirclFi. Same-industry comparisons provide the most direct insight into relative valuation since both companies face similar regulatory environments, market dynamics, and competitive pressures. Both companies are analyzed with models spanning intrinsic (Bayesian DCF, EPV), scenario-based (First Chicago), regime-switching (Markov DDM, RCMH-DCF), machine learning (ML-RIV, FTNN), and ensemble methods (CUCE).

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