SNTI vs SPRO

Senti Biosciences Holdings, Inc vs Spero Therapeutics, Inc. — Valuation Comparison 2026

By CirclFi Research Team · Updated 2026-06-03 · Data from SEC EDGAR, FRED & GDELT

Quick Summary — SPRO scores higher on quality with 7.5/10 vs SNTI's 4.1/10. SNTI trades at $0.98 while SPRO trades at $2.83. Both analyzed daily using SEC EDGAR data across 13 institutional models.

SNTI

Biotechnology
Senti Biosciences Holdings, Inc
Quality
4.1
out of 10
Value Trap
39
LOW
Price
$0.98
Last close
Models
9/13
Active
VS

SPRO

Biotechnology
Spero Therapeutics, Inc.
Quality
7.5
out of 10
Value Trap
48
WARN
Price
$2.83
Last close
Models
10/13
Active
SNTI
2 models active
Quality 4.1/10 — below average
SPRO
2 models active
Value Trap 48/100 — caution

SNTI vs SPRO — Fair Value Comparison

SNTI
$0$0$1$1 Price$0.98 Bayesian …$0.52 (-48.4%) Dynamic N…$0.06 (-93.6%)
SPRO
$0$1$2$3 Price$2.83 Bayesian …$1.25 (-55.9%) Dynamic N…$1.96 (-30.6%)
Market Price Model 1 Model 2

Model-by-Model Comparison

ModelType SNTI Fair ValueSNTI Upside SPRO Fair ValueSPRO Upside
Bayesian DCF Intrinsic $0.52 -48.4% $1.25 -55.9%
First Chicago Scenario $•••.•• ••.•% $•••.•• ••.•%
ML-RIV Intrinsic $•••.•• ••.•% $•••.•• ••.•%
Dynamic NAV Asset-Based $0.06 -93.6% $1.96 -30.6%
PWERM Option-Based $•••.•• ••.•% $•••.•• ••.•%
Regime Cross-Sectional Relative $•••.•• ••.•% $•••.•• ••.•%
Sentiment SOTP Hybrid $•••.•• ••.•% $•••.•• ••.•%
CUCE Ensemble Ensemble $•••.•• ••.•% $•••.•• ••.•%
FTNN Topology Relative $•••.•• ••.•% $•••.•• ••.•%
RCMH-DCF Intrinsic $•••.•• ••.•% $•••.•• ••.•%

SNTI vs SPRO — Which Stock Is More Undervalued in 2026?

SPRO scores higher with a 7.5/10 quality rating vs SNTI's 4.1/10. Both stocks are analyzed daily using SEC EDGAR filings across 13 independent models.

How Do SNTI and SPRO Valuations Compare?

At $0.98, SNTI trades +48.4% above its Bayesian DCF fair value of $0.52, while SPRO at $2.83 trades +55.9% above its estimate of $1.25. SPRO shows a wider gap between price and intrinsic value.

Quality of Company: SNTI vs SPRO

SNTI earns a Quality of Company score of 4.1/10 compared to SPRO's 7.5/10. This is a significant quality gap — the higher-scoring company demonstrates materially stronger fundamentals across profitability, growth consistency, and balance sheet health. The QOC score synthesizes 32 signals spanning profitability margins, revenue growth, free cash flow, capital allocation, and leverage.

Value Trap Risk: SNTI vs SPRO

SNTI carries a LOW value trap risk (39/100) while SPRO shows WARN risk (48/100). Stocks with value trap scores above 40 may appear undervalued but face deteriorating fundamentals — declining margins, rising debt, or shrinking revenue can make the apparent discount a trap.

Both in Biotechnology

Both SNTI and SPRO operate in Biotechnology, which has 566 stocks tracked by CirclFi. Same-industry comparisons provide the most direct insight into relative valuation since both companies face similar regulatory environments, market dynamics, and competitive pressures. Both companies are analyzed with models spanning intrinsic (Bayesian DCF, EPV), scenario-based (First Chicago), regime-switching (Markov DDM, RCMH-DCF), machine learning (ML-RIV, FTNN), and ensemble methods (CUCE).

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SNTI
View Full Senti Biosciences Holdings, Inc Analysis →
SPRO
View Full Spero Therapeutics, Inc. Analysis →
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