Is SION or SKYE more undervalued in 2026?

CirclFi compares Sionna Therapeutics, Inc. (SION) and Skye Bioscience, Inc. (SKYE) using 13 institutional-grade valuation models. SION has a Quality of Company score of 4.3/10 while SKYE scores 3.6/10.

Which is a better buy — SION or SKYE?

Compare intrinsic values from 13 independent models against current market prices. CirclFi also calculates Value Trap scores. This is not financial advice — conduct your own analysis.

How do SION and SKYE valuations compare?

SION at $42.80 and SKYE at $0.85 are compared across Bayesian DCF, EPV, EROIC Spread, First Chicago, Markov DDM, and 8 additional models.

SION vs SKYE Valuation Comparison 2026 — Intrinsic Value Analysis

SION

Biotechnology

Sionna Therapeutics, Inc.

Quality

4.3

out of 10

Value Trap

—

Price

$42.80

Last close

Models

10/13

Active

SKYE

Biotechnology

Skye Bioscience, Inc.

Quality

3.6

out of 10

Value Trap

LOW

Price

$0.85

Last close

Models

7/13

Active

Model-by-Model Comparison

Model	Type	SION Fair Value	SION Upside	SKYE Fair Value	SKYE Upside
Bayesian DCF	Intrinsic	$8.06	-81.2%	$0.21	-74.8%
Earnings Power Value	Intrinsic	$15.97	-58.1%	—	—
EROIC Spread	Intrinsic	$•••.••	••.•%	$•••.••	••.•%
First Chicago	Scenario	$•••.••	••.•%	$•••.••	••.•%
Markov DDM	Intrinsic	$•••.••	••.•%	$•••.••	••.•%
ML-RIV	Intrinsic	$•••.••	••.•%	$•••.••	••.•%
Dynamic NAV	Asset-Based	$4.47	-88.6%	$1.84	+116.7%
PWERM	Option-Based	$•••.••	••.•%	$•••.••	••.•%
Sentiment SOTP	Hybrid	$•••.••	••.•%	$•••.••	••.•%
CUCE Ensemble	Ensemble	$•••.••	••.•%	$•••.••	••.•%

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SION vs SKYE — Which Stock Is More Undervalued?

SION scores higher with a 4.3/10 quality rating vs SKYE's 3.6/10. Both stocks are analyzed daily using SEC EDGAR filings across 13 independent models.

Comparing Sionna Therapeutics, Inc. (SION) and Skye Bioscience, Inc. (SKYE) across 13 institutional-grade valuation models reveals how each company's intrinsic value stacks up against its market price. CirclFi's engine processes SEC EDGAR 10-K and 10-Q filings, FRED macroeconomic data, and GDELT news sentiment to generate independent fair value estimates daily.

SION currently trades at $42.80 with a QOC of 4.3/10, while SKYE trades at $0.85 with a QOC of 3.6/10.

Both companies are analyzed with models spanning intrinsic (Bayesian DCF, EPV), scenario-based (First Chicago), regime-switching (Markov DDM, RCMH-DCF), machine learning (ML-RIV, FTNN Topology), and ensemble methods (CUCE).