Is SHPH or SKYE more undervalued in 2026?

CirclFi compares Shuttle Pharmaceuticals Holding (SHPH) and Skye Bioscience, Inc. (SKYE) using 13 institutional-grade valuation models. SHPH has a Quality of Company score of 3.6/10 while SKYE scores 3.6/10.

Which is a better buy — SHPH or SKYE?

Compare intrinsic values from 13 independent models against current market prices. CirclFi also calculates Value Trap scores. This is not financial advice — conduct your own analysis.

How do SHPH and SKYE valuations compare?

SHPH at $0.53 and SKYE at $0.78 are compared across Bayesian DCF, EPV, EROIC Spread, First Chicago, Markov DDM, and 8 additional models.

SHPH vs SKYE Valuation Comparison 2026 — Intrinsic Value Analysis

SHPH

Pharmaceutical Preparations

Shuttle Pharmaceuticals Holding

Quality

3.6

out of 10

Value Trap

SAFE

Price

$0.53

Last close

Models

8/13

Active

SKYE

Pharmaceutical Preparations

Skye Bioscience, Inc.

Quality

3.6

out of 10

Value Trap

LOW

Price

$0.78

Last close

Models

7/13

Active

Model-by-Model Comparison

Model	Type	SHPH Fair Value	SHPH Upside	SKYE Fair Value	SKYE Upside
Bayesian DCF	Intrinsic	$3.22	+464.6%	$0.20	-73.9%
First Chicago	Scenario	$•••.••	••.•%	$•••.••	••.•%
ML-RIV	Intrinsic	$0.08	-88.0%	$0.08	-90.5%
Dynamic NAV	Asset-Based	$0.52	-24.7%	$1.84	+137.5%
PWERM	Option-Based	$•••.••	••.•%	$•••.••	••.•%
Sentiment SOTP	Hybrid	$•••.••	••.•%	$•••.••	••.•%
CUCE Ensemble	Ensemble	$•••.••	••.•%	$•••.••	••.•%
FTNN Topology	Relative	$•••.••	••.•%	$•••.••	••.•%

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SHPH vs SKYE — Which Stock Is More Undervalued?

SHPH scores higher with a 3.6/10 quality rating vs SKYE's 3.6/10. Both stocks are analyzed daily using SEC EDGAR filings across 13 independent models.

Comparing Shuttle Pharmaceuticals Holding (SHPH) and Skye Bioscience, Inc. (SKYE) across 13 institutional-grade valuation models reveals how each company's intrinsic value stacks up against its market price. CirclFi's engine processes SEC EDGAR 10-K and 10-Q filings, FRED macroeconomic data, and GDELT news sentiment to generate independent fair value estimates daily.

SHPH currently trades at $0.53 with a QOC of 3.6/10, while SKYE trades at $0.78 with a QOC of 3.6/10.

Both companies are analyzed with models spanning intrinsic (Bayesian DCF, EPV), scenario-based (First Chicago), regime-switching (Markov DDM, RCMH-DCF), machine learning (ML-RIV, FTNN Topology), and ensemble methods (CUCE).