Is SHPH or SION more undervalued in 2026?

CirclFi compares Shuttle Pharmaceuticals Holding (SHPH) and Sionna Therapeutics, Inc. (SION) using 13 institutional-grade valuation models. SHPH has a Quality of Company score of 3.6/10 while SION scores 4.3/10.

Which is a better buy — SHPH or SION?

Compare intrinsic values from 13 independent models against current market prices. CirclFi also calculates Value Trap scores. This is not financial advice — conduct your own analysis.

How do SHPH and SION valuations compare?

SHPH at $0.53 and SION at $42.82 are compared across Bayesian DCF, EPV, EROIC Spread, First Chicago, Markov DDM, and 8 additional models.

SHPH vs SION Valuation Comparison 2026 — Intrinsic Value Analysis

SHPH

Pharmaceutical Preparations

Shuttle Pharmaceuticals Holding

Quality

3.6

out of 10

Value Trap

SAFE

Price

$0.53

Last close

Models

8/13

Active

SION

Pharmaceutical Preparations

Sionna Therapeutics, Inc.

Quality

4.3

out of 10

Value Trap

—

Price

$42.82

Last close

Models

10/13

Active

Model-by-Model Comparison

Model	Type	SHPH Fair Value	SHPH Upside	SION Fair Value	SION Upside
Bayesian DCF	Intrinsic	$3.22	+464.6%	$7.15	-83.3%
Earnings Power Value	Intrinsic	—	—	$15.97	-58.1%
EROIC Spread	Intrinsic	$•••.••	••.•%	$•••.••	••.•%
First Chicago	Scenario	$•••.••	••.•%	$•••.••	••.•%
Markov DDM	Intrinsic	$•••.••	••.•%	$•••.••	••.•%
ML-RIV	Intrinsic	$0.08	-88.0%	$2.07	-94.7%
Dynamic NAV	Asset-Based	$•••.••	••.•%	$•••.••	••.•%
PWERM	Option-Based	$•••.••	••.•%	$•••.••	••.•%
Sentiment SOTP	Hybrid	$•••.••	••.•%	$•••.••	••.•%
CUCE Ensemble	Ensemble	$•••.••	••.•%	$•••.••	••.•%
FTNN Topology	Relative	$•••.••	••.•%	$•••.••	••.•%

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SHPH vs SION — Which Stock Is More Undervalued?

SION scores higher with a 4.3/10 quality rating vs SHPH's 3.6/10. Both stocks are analyzed daily using SEC EDGAR filings across 13 independent models.

Comparing Shuttle Pharmaceuticals Holding (SHPH) and Sionna Therapeutics, Inc. (SION) across 13 institutional-grade valuation models reveals how each company's intrinsic value stacks up against its market price. CirclFi's engine processes SEC EDGAR 10-K and 10-Q filings, FRED macroeconomic data, and GDELT news sentiment to generate independent fair value estimates daily.

SHPH currently trades at $0.53 with a QOC of 3.6/10, while SION trades at $42.82 with a QOC of 4.3/10.

Both companies are analyzed with models spanning intrinsic (Bayesian DCF, EPV), scenario-based (First Chicago), regime-switching (Markov DDM, RCMH-DCF), machine learning (ML-RIV, FTNN Topology), and ensemble methods (CUCE).