Is PHIO or PLYX more undervalued in 2026?

CirclFi compares Phio Pharmaceuticals Corp. (PHIO) and Polaryx Therapeutics, Inc. (PLYX) using 13 institutional-grade valuation models. PHIO has a Quality of Company score of 3.7/10 while PLYX scores 4.3/10.

Which is a better buy — PHIO or PLYX?

Compare intrinsic values from 13 independent models against current market prices. CirclFi also calculates Value Trap scores. This is not financial advice — conduct your own analysis.

How do PHIO and PLYX valuations compare?

PHIO at $1.14 and PLYX at $3.05 are compared across Bayesian DCF, EPV, EROIC Spread, First Chicago, Markov DDM, and 8 additional models.

PHIO vs PLYX Valuation Comparison 2026 — Intrinsic Value Analysis

PHIO

Biotechnology

Phio Pharmaceuticals Corp.

Quality

3.7

out of 10

Value Trap

LOW

Price

$1.14

Last close

Models

7/13

Active

PLYX

Biotechnology

Polaryx Therapeutics, Inc.

Quality

4.3

out of 10

Value Trap

—

Price

$3.05

Last close

Models

8/13

Active

Model-by-Model Comparison

Model	Type	PHIO Fair Value	PHIO Upside	PLYX Fair Value	PLYX Upside
Bayesian DCF	Intrinsic	$1.11	-2.8%	$0.84	-72.4%
First Chicago	Scenario	$•••.••	••.•%	$•••.••	••.•%
ML-RIV	Intrinsic	$•••.••	••.•%	$•••.••	••.•%
Dynamic NAV	Asset-Based	$1.64	+43.8%	$0.19	-93.8%
PWERM	Option-Based	$•••.••	••.•%	$•••.••	••.•%
Sentiment SOTP	Hybrid	$•••.••	••.•%	$•••.••	••.•%
CUCE Ensemble	Ensemble	$•••.••	••.•%	$•••.••	••.•%
FTNN Topology	Relative	$•••.••	••.•%	$•••.••	••.•%
RCMH-DCF	Intrinsic	$•••.••	••.•%	$•••.••	••.•%

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PHIO vs PLYX — Which Stock Is More Undervalued?

PLYX scores higher with a 4.3/10 quality rating vs PHIO's 3.7/10. Both stocks are analyzed daily using SEC EDGAR filings across 13 independent models.

Comparing Phio Pharmaceuticals Corp. (PHIO) and Polaryx Therapeutics, Inc. (PLYX) across 13 institutional-grade valuation models reveals how each company's intrinsic value stacks up against its market price. CirclFi's engine processes SEC EDGAR 10-K and 10-Q filings, FRED macroeconomic data, and GDELT news sentiment to generate independent fair value estimates daily.

PHIO currently trades at $1.14 with a QOC of 3.7/10, while PLYX trades at $3.05 with a QOC of 4.3/10.

Both companies are analyzed with models spanning intrinsic (Bayesian DCF, EPV), scenario-based (First Chicago), regime-switching (Markov DDM, RCMH-DCF), machine learning (ML-RIV, FTNN Topology), and ensemble methods (CUCE).