KPTI vs KRYS

Karyopharm Therapeutics Inc. vs Krystal Biotech, Inc. — Valuation Comparison 2026

By CirclFi Research Team · Updated 2026-06-03 · Data from SEC EDGAR, FRED & GDELT

Quick Summary — KRYS scores higher on quality with 7.7/10 vs KPTI's 5.1/10. KPTI trades at $9.23 while KRYS trades at $293.21. Both analyzed daily using SEC EDGAR data across 13 institutional models.

KPTI

Biotechnology
Karyopharm Therapeutics Inc.
Quality
5.1
out of 10
Value Trap
30
LOW
Price
$9.23
Last close
Models
7/13
Active
VS

KRYS

Biotechnology
Krystal Biotech, Inc.
Quality
7.7
out of 10
Value Trap
6
SAFE
Price
$293.21
Last close
Models
13/13
Active
KPTI
PWERM sees +173.0% upside
Limited to 2/13 visible models
KRYS
2 models active
Limited to 2/13 visible models

KPTI vs KRYS — Fair Value Comparison

KPTI
$0$10$20$30 Price$9.23 Bayesian …$3.33 (-64.0%) PWERM$25.20 (+173.0%)
KRYS
$0$115$231$346 Price$293.21 Bayesian …$134.73 (-54.0%) Earnings …$60.74 (-79.3%)
Market Price Model 1 Model 2

Model-by-Model Comparison

ModelType KPTI Fair ValueKPTI Upside KRYS Fair ValueKRYS Upside
Bayesian DCF Intrinsic $3.33 -64.0% $134.73 -54.0%
Earnings Power Value Intrinsic $60.74 -79.3%
EROIC Spread Intrinsic $•••.•• ••.•% $•••.•• ••.•%
First Chicago Scenario $•••.•• ••.•% $•••.•• ••.•%
Markov DDM Intrinsic $•••.•• ••.•% $•••.•• ••.•%
ML-RIV Intrinsic $•••.•• ••.•% $•••.•• ••.•%
Dynamic NAV Asset-Based $•••.•• ••.•% $•••.•• ••.•%
PWERM Option-Based $25.20 +173.0% $280.88 -4.2%
Regime Cross-Sectional Relative $•••.•• ••.•% $•••.•• ••.•%
Sentiment SOTP Hybrid $•••.•• ••.•% $•••.•• ••.•%
CUCE Ensemble Ensemble $•••.•• ••.•% $•••.•• ••.•%
FTNN Topology Relative $•••.•• ••.•% $•••.•• ••.•%
RCMH-DCF Intrinsic $•••.•• ••.•% $•••.•• ••.•%

KPTI vs KRYS — Which Stock Is More Undervalued in 2026?

KRYS scores higher with a 7.7/10 quality rating vs KPTI's 5.1/10. Both stocks are analyzed daily using SEC EDGAR filings across 13 independent models.

How Do KPTI and KRYS Valuations Compare?

At $9.23, KPTI trades +64.0% above its Bayesian DCF fair value of $3.33, while KRYS at $293.21 trades +54.0% above its estimate of $134.73. KPTI shows a wider gap between price and intrinsic value.

Quality of Company: KPTI vs KRYS

KPTI earns a Quality of Company score of 5.1/10 compared to KRYS's 7.7/10. This moderate difference suggests one company has an edge in fundamental quality, though both may offer investment merit depending on valuation. The QOC score synthesizes 32 signals spanning profitability margins, revenue growth, free cash flow, capital allocation, and leverage.

Value Trap Risk: KPTI vs KRYS

KPTI carries a LOW value trap risk (30/100) while KRYS shows SAFE risk (6/100). Both companies show manageable value trap risk, suggesting their current valuations are not artificially depressed by fundamental deterioration.

Both in Biotechnology

Both KPTI and KRYS operate in Biotechnology, which has 566 stocks tracked by CirclFi. Same-industry comparisons provide the most direct insight into relative valuation since both companies face similar regulatory environments, market dynamics, and competitive pressures. Both companies are analyzed with models spanning intrinsic (Bayesian DCF, EPV), scenario-based (First Chicago), regime-switching (Markov DDM, RCMH-DCF), machine learning (ML-RIV, FTNN), and ensemble methods (CUCE).

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