Is IONS or IVA more undervalued in 2026?

CirclFi compares Ionis Pharmaceuticals, Inc. (IONS) and Inventiva S.A. - American Depos (IVA) using 13 institutional-grade valuation models. IONS has a Quality of Company score of 3.6/10 while IVA scores 4.4/10.

Which is a better buy — IONS or IVA?

Compare intrinsic values from 13 independent models against current market prices. CirclFi also calculates Value Trap scores. This is not financial advice — conduct your own analysis.

How do IONS and IVA valuations compare?

IONS at $77.33 and IVA at $5.23 are compared across Bayesian DCF, EPV, EROIC Spread, First Chicago, Markov DDM, and 8 additional models.

IONS vs IVA Valuation Comparison 2026 — Intrinsic Value Analysis

IONS

Biotechnology

Ionis Pharmaceuticals, Inc.

Quality

3.6

out of 10

Value Trap

SAFE

Price

$77.33

Last close

Models

12/13

Active

IVA

Biotechnology

Inventiva S.A. - American Depos

Quality

4.4

out of 10

Value Trap

SAFE

Price

$5.23

Last close

Models

7/13

Active

Model-by-Model Comparison

Model	Type	IONS Fair Value	IONS Upside	IVA Fair Value	IVA Upside
Bayesian DCF	Intrinsic	$26.36	-65.9%	$0.59	-88.8%
Earnings Power Value	Intrinsic	$36.24	-50.5%	—	—
EROIC Spread	Intrinsic	$•••.••	••.•%	$•••.••	••.•%
First Chicago	Scenario	$•••.••	••.•%	$•••.••	••.•%
Markov DDM	Intrinsic	$•••.••	••.•%	$•••.••	••.•%
ML-RIV	Intrinsic	$•••.••	••.•%	$•••.••	••.•%
Dynamic NAV	Asset-Based	$•••.••	••.•%	$•••.••	••.•%
PWERM	Option-Based	$90.32	+16.8%	$5.93	+13.4%
Regime Cross-Sectional	Relative	$•••.••	••.•%	$•••.••	••.•%
Sentiment SOTP	Hybrid	$•••.••	••.•%	$•••.••	••.•%
CUCE Ensemble	Ensemble	$•••.••	••.•%	$•••.••	••.•%
FTNN Topology	Relative	$•••.••	••.•%	$•••.••	••.•%

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IONS vs IVA — Which Stock Is More Undervalued?

IVA scores higher with a 4.4/10 quality rating vs IONS's 3.6/10. Both stocks are analyzed daily using SEC EDGAR filings across 13 independent models.

Comparing Ionis Pharmaceuticals, Inc. (IONS) and Inventiva S.A. - American Depos (IVA) across 13 institutional-grade valuation models reveals how each company's intrinsic value stacks up against its market price. CirclFi's engine processes SEC EDGAR 10-K and 10-Q filings, FRED macroeconomic data, and GDELT news sentiment to generate independent fair value estimates daily.

IONS currently trades at $77.33 with a QOC of 3.6/10, while IVA trades at $5.23 with a QOC of 4.4/10.

Both companies are analyzed with models spanning intrinsic (Bayesian DCF, EPV), scenario-based (First Chicago), regime-switching (Markov DDM, RCMH-DCF), machine learning (ML-RIV, FTNN Topology), and ensemble methods (CUCE).