BMEA vs BYSI

Biomea Fusion, Inc. vs BeyondSpring, Inc. — Valuation Comparison 2026

By CirclFi Research Team · Updated 2026-06-03 · Data from SEC EDGAR, FRED & GDELT

Quick Summary — BMEA scores higher on quality with 4.0/10 vs BYSI's 3.5/10. BMEA trades at $1.37 while BYSI trades at $1.70. Both analyzed daily using SEC EDGAR data across 13 institutional models.

BMEA

Biotechnology
Biomea Fusion, Inc.
Quality
4.0
out of 10
Value Trap
24
SAFE
Price
$1.37
Last close
Models
9/13
Active
VS

BYSI

Biotechnology
BeyondSpring, Inc.
Quality
3.5
out of 10
Value Trap
24
SAFE
Price
$1.70
Last close
Models
10/13
Active
BMEA
2 models active
Quality 4.0/10 — below average
BYSI
Bayesian DCF sees +152.2% upside
Quality 3.5/10 — below average

BMEA vs BYSI — Fair Value Comparison

BMEA
$0$1$1$2 Price$1.37 Bayesian …$0.51 (-63.1%) Earnings …$1.22 (-10.6%)
BYSI
$0$1$3$4 Price$1.70 Bayesian …$3.63 (+152.2%) Earnings …$0.75 (-49.6%)
Market Price Model 1 Model 2

Model-by-Model Comparison

ModelType BMEA Fair ValueBMEA Upside BYSI Fair ValueBYSI Upside
Bayesian DCF Intrinsic $0.51 -63.1% $3.63 +152.2%
Earnings Power Value Intrinsic $1.22 -10.6% $0.75 -49.6%
EROIC Spread Intrinsic $•••.•• ••.•% $•••.•• ••.•%
First Chicago Scenario $•••.•• ••.•% $•••.•• ••.•%
ML-RIV Intrinsic $•••.•• ••.•% $•••.•• ••.•%
Dynamic NAV Asset-Based $•••.•• ••.•% $•••.•• ••.•%
PWERM Option-Based $•••.•• ••.•% $•••.•• ••.•%
Regime Cross-Sectional Relative $•••.•• ••.•% $•••.•• ••.•%
Sentiment SOTP Hybrid $•••.•• ••.•% $•••.•• ••.•%
CUCE Ensemble Ensemble $•••.•• ••.•% $•••.•• ••.•%
RCMH-DCF Intrinsic $•••.•• ••.•% $•••.•• ••.•%

BMEA vs BYSI — Which Stock Is More Undervalued in 2026?

BMEA scores higher with a 4.0/10 quality rating vs BYSI's 3.5/10. Both stocks are analyzed daily using SEC EDGAR filings across 13 independent models.

How Do BMEA and BYSI Valuations Compare?

At $1.37, BMEA trades +63.1% above its Bayesian DCF fair value of $0.51, while BYSI at $1.70 trades +152.2% below its estimate of $3.63. BYSI shows a wider gap between price and intrinsic value.

Quality of Company: BMEA vs BYSI

BMEA earns a Quality of Company score of 4.0/10 compared to BYSI's 3.5/10. The scores are closely matched, indicating similar fundamental quality profiles. The QOC score synthesizes 32 signals spanning profitability margins, revenue growth, free cash flow, capital allocation, and leverage.

Value Trap Risk: BMEA vs BYSI

BMEA carries a SAFE value trap risk (24/100) while BYSI shows SAFE risk (24/100). Both companies show manageable value trap risk, suggesting their current valuations are not artificially depressed by fundamental deterioration.

Both in Biotechnology

Both BMEA and BYSI operate in Biotechnology, which has 566 stocks tracked by CirclFi. Same-industry comparisons provide the most direct insight into relative valuation since both companies face similar regulatory environments, market dynamics, and competitive pressures. Both companies are analyzed with models spanning intrinsic (Bayesian DCF, EPV), scenario-based (First Chicago), regime-switching (Markov DDM, RCMH-DCF), machine learning (ML-RIV, FTNN), and ensemble methods (CUCE).

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